This square dates back to the first half of the 17th century. Its location, just a few metres from the bay, led to it becoming an important trading square over the years. It is said that around the year 1600 the first fountain of the city could be seen at this square. In 1836 it was replaced by a beautiful fountain made of white Carrara marble by Giuseppe Gaggini, under the good auspices of the Villanueva Count. This fountain is called Fuente de los Leones (Lions Fountain). On its paved area stand two noteworthy buildings: the Monastery and Basilica of San Francisco de Asís, which today houses the Museum of Religious Art and a concert hall. It is also where the Lonja del Comercio (Chamber of Commerce) is located, inspired by Spanish Renaissance architecture and topped by a dome on which a sculpture of the god Mercury stands. Among the houses built around the plaza, the house of the Arostegui family, residence of the Captain Generals until the completion of the City Hall at the end of the 18th century, was erected.

The Templete, a small neo-classical style construction, was built in the second half of the 18th Century. It is located in Plaza de Armas. This was the site where the first public mass was celebrated and also the site of the first town council of the nascent town of San Cristóbal de La Habana. The Templete resembles a Doric temple and houses three commemorative canvasses by the famous French painter Juan Bautista Vermey. One of the walls exhibits the plate that declares Old Havana a World Heritage Site.

The San Francisco de Asís Church and Convent is the current scenario of the richest cultural traditions. This is one of the most extraordinary convent and church complex of the colonial time. The construction of the current set dates from 1738, and it replaced a more modest one completed in 1591. After a restoration in the nineties, the architectural group has harbored, also, a concert hall and the Holy, Sacred and Religious Art museums. The most significant element of the Church is the Tower 42 meters of height, second in altitude at the colonial time. 

A few steps towards Calle Brasil from Plaza del Cristo Square is where the 1886 Museo de la Farmacia Habanera is located. Founded by the Catalonian José Sarrá, it is a shop-museum and nowadays still functions as a pharmacy. The museum displays the history of pharmacies in Havana and their evolution in Cuba. This Pharmacy preserves its original Neo-gothic furniture with Moorish influences, and host a large collection of medicine bottles and medical tools, extracted from archeological excavations in the old city, as well as a book collection with valuable prescriptions for the study of Cuban pharmacopoeia. The museum also exhibits an elegant scale model of an old pharmacy with captivating historical explanations.